In Our Time: Science

Melvyn Bragg and his guests discuss the Hippocratic Oath. The Greek physician Hippocrates, active in the fifth century BC, has been described as the father of medicine, although little is known about his life and some scholars even argue that he was not one person but several. A large body of work originally attributed to him, the Hippocratic Corpus, was disseminated widely in the ancient world, and contains treatises on a wide variety of subjects, from fractures to medical ethics.Today we know that the Hippocratic Corpus cannot have been written by a single author. But many of its texts shaped Western medicine for centuries. The best known is the Hippocratic Oath, an ethical code for doctors. Celebrated in the ancient world, and later referred to by Arabic scholars, it offers medics guidance on how they should behave. Although it has often been revised and adapted, the Hippocratic Oath remains one of the most significant and best known documents of medical science - but there is little evidence that it was r

Melvyn Bragg and his guests discuss the origins of infectious disease. Infectious disease has been with us for millennia. There are reports of ancient outbreaks of plague in the Bible, and in numerous historical sources from China, the Middle East and Europe. Other infections, including smallpox, tuberculosis and measles, have also been known for centuries. But some diseases made their first appearances only recently: HIV emerged around a century ago, while the Ebola virus was first recorded in the 1970s.But where do the agents of disease come from, and what determines where and when new viruses and bacteria appear? Modern techniques allow scientists to trace the histories of infective agents through their genomes; the story of disease provides a fascinating microcosm of the machinery of evolution.With:Steve JonesProfessor of Genetics at University College LondonSir Roy AndersonProfessor of Infectious Disease Epidemiology at Imperial College LondonMark PallenProfessor of Microbial Genomics at the University o

Melvyn Bragg and his guests discuss the neutrino.In 1930 the physicist Wolfgang Pauli proposed the existence of an as-yet undiscovered subatomic particle. He also bet his colleagues a case of champagne that it would never be detected. He lost his bet when in 1956 the particle, now known as the neutrino, was first observed in an American nuclear reactor. Neutrinos are some of the most mysterious particles in the Universe. The Sun produces trillions of them every second, and they constantly bombard the Earth and everything on it. Neutrinos can pass through solid rock, and even stars, at almost the speed of light without being impeded, and are almost impossible to detect. Today, experiments involving neutrinos are providing insights into the nature of matter, the contents of the Universe and the processes deep inside stars.With:Frank CloseProfessor of Physics at Exeter College at the University of OxfordSusan CartwrightSenior Lecturer in Particle Physics and Astrophysics at the University of SheffieldDavid WarkP

Melvyn Bragg and his guests discuss the age of the Universe.Since the 18th century, when scientists first realised that the Universe had existed for more than a few thousand years, cosmologists have debated its likely age. The discovery that the Universe was expanding allowed the first informed estimates of its age to be made by the great astronomer Edwin Hubble in the early decades of the twentieth century. Hubble's estimate of the rate at which the Universe is expanding, the so-called Hubble Constant, has been progressively improved. Today cosmologists have a variety of other methods for ageing the Universe, most recently the detailed measurements of cosmic microwave background radiation - the afterglow of the Big Bang - made in the last decade. And all these methods seem to agree on one thing: the Universe has existed for around 13.75 billion years.With:Martin ReesAstronomer Royal and Emeritus Professor of Cosmology and Astrophysics at the University of CambridgeCarolin CrawfordMember of the Institute of A

Melvyn Bragg and his guests discuss the nervous system.Most animals have a nervous system, a network of nerve tissues which allows parts of the body to communicate with each other. In humans the most significant parts of this network are the brain, spinal column and retinas, which together make up the central nervous system. But there is also a peripheral nervous system, which enables sensation, movement and the regulation of the major organs.Scholars first described the nerves of the human body over two thousand years ago. For 1400 years it was believed that they were animated by 'animal spirits', mysterious powers which caused sensation and movement. In the eighteenth century scientists discovered that nerve fibres transmitted electrical impulses; it was not until the twentieth century that chemical agents - neurotransmitters - were first identified.With:Colin Blakemore Professor of Neuroscience at the University of OxfordVivian Nutton Emeritus Professor of the History of Medicine at University College, Lon

Melvyn Bragg and his guests discuss randomness and pseudorandomness.Randomness is the mathematics of the unpredictable. Dice and roulette wheels produce random numbers: those which are unpredictable and display no pattern. But mathematicians also talk of 'pseudorandom' numbers - those which appear to be random but are not. In the last century random numbers have become enormously useful to statisticians, computer scientists and cryptographers. But true randomness is difficult to find, and mathematicians have devised many ingenious solutions to harness or simulate it. These range from the Premium Bonds computer ERNIE (whose name stands for Electronic Random Number Indicator Equipment) to new methods involving quantum physics.Digital computers are incapable of behaving in a truly random fashion - so instead mathematicians have taught them how to harness pseudorandomness. This technique is used daily by weather forecasters, statisticians, and computer chip designers - and it's thanks to pseudorandomness that sec

Melvyn Bragg and his guests discuss the innovations and influence of Thomas Edison, one of the architects of the modern age.Edison is popularly remembered as the man who made cheap electric light possible. Born in 1847, he began his career working in the new industry of telegraphy, and while still in his early twenties made major improvements to the technology of the telegraph. Not long afterwards he invented a new type of microphone which was used in telephones for almost a century. In the space of three productive years, Edison developed the phonograph and the first commercially viable light bulb and power distribution system. Many more inventions were to follow: he also played a part in the birth of cinema in the 1890s. When he died in 1931 he had patented no fewer than 1093 devices - the most prolific inventor in history. As the creator of the world's first industrial research laboratory he forever changed the way in which innovation took place.With:Simon SchafferProfessor of the History of Science, Unive

Melvyn Bragg and his guests discuss the role played by women in Enlightenment science. During the eighteenth century the opportunities for women to gain a knowledge of science were minimal. Universities and other institutions devoted to research were the preserve of men. Yet many important contributions to the science of the Enlightenment were made by women. These ranged from major breakthroughs like those of the British astronomer Caroline Herschel, the first woman to discover a comet, to important translations of scientific literature such as Emilie du Chatelet's French version of Newton's Principia - and all social classes were involved, from the aristocratic amateur botanists to the women artisans who worked in London's workshops manufacturing scientific instruments. The image above, of Emilie du Chatelet, is attributed to Maurice Quentin de La Tour.WithPatricia Fara Senior Tutor at Clare College, University of CambridgeKaren O'Brien Professor of English at the University of WarwickJudith Hawley Professor

Melvyn Bragg and his guests discuss the history of logic. Logic, the study of reasoning and argument, first became a serious area of study in the 4th century BC through the work of Aristotle. He created a formal logical system, based on a type of argument called a syllogism, which remained in use for over two thousand years. In the nineteenth century the German philosopher and mathematician Gottlob Frege revolutionised logic, turning it into a discipline much like mathematics and capable of dealing with expressing and analysing nuanced arguments. His discoveries influenced the greatest mathematicians and philosophers of the twentieth century and considerably aided the development of the electronic computer. Today logic is a subtle system with applications in fields as diverse as mathematics, philosophy, linguistics and artificial intelligence.With:A.C. GraylingProfessor of Philosophy at Birkbeck, University of LondonPeter MillicanGilbert Ryle Fellow in Philosophy at Hertford College at the University of Oxfor

Melvyn Bragg and his guests discuss imaginary numbers. In the sixteenth century, a group of mathematicians in Bologna found a solution to a problem that had puzzled generations before them: a completely new kind of number. For more than a century this discovery was greeted with such scepticism that the great French thinker Rene Descartes dismissed it as an "imaginary" number.The name stuck - but so did the numbers. Long dismissed as useless or even fictitious, the imaginary number i and its properties were first explored seriously in the eighteenth century. Today the imaginary numbers are in daily use by engineers, and are vital to our understanding of phenomena including electricity and radio waves. With Marcus du SautoyProfessor of Mathematics at Oxford University Ian StewartEmeritus Professor of Mathematics at the University of WarwickCaroline SeriesProfessor of Mathematics at the University of WarwickProducer: Thomas Morris.

Melvyn Bragg and his guests discuss Pliny's Natural History.Some time in the first century AD, the Roman scholar Pliny the Elder published his Naturalis Historia, or Natural History, an enormous reference work which attempted to bring together knowledge on every subject under the sun. The Natural History contains information on zoology, astronomy, geography, minerals and mining and - unusually for a work of this period - a detailed treatise on the history of classical art. It's a fascinating snapshot of the state of human knowledge almost two millennia ago.Pliny's 37-volume magnum opus is one of the most extensive works of classical scholarship to survive in its entirety, and was being consulted by scholars as late as the Renaissance. It had a significant influence on intellectual history, and has provided the template for every subsequent encyclopaedia.With:Serafina CuomoReader in Roman History at Birkbeck, University of LondonAude DoodyLecturer in Classics at University College, DublinLiba TaubReader in the

Melvyn Bragg and his guests discuss the history of Antarctica.The most southerly of the continents is the bleakest and coldest place on Earth. Almost entirely covered in ice, Antarctica spends much of the winter in total darkness.Antarctica was first named in the second century AD by the geographer Marinus of Tyre, who was one of many early geographers to speculate about the existence of a huge southern landmass to balance the known lands of northern Europe. But it wasn't until the nineteenth century that modern man laid eyes on the continent.In the intervening two hundred years the continent has been the scene for some of the most famous - and tragic - events of human exploration. In 1959 an international treaty declared Antarctica a scientific reserve, set aside for peaceful use by any nation willing to subscribe to the terms of the agreement.With: Jane FrancisProfessor of Paleoclimatology at the University of LeedsJulian DowdeswellDirector of the Scott Polar Research Institute and Professor of Physical Geo

Melvyn Bragg and his guests discuss the Neanderthals.In 1856, quarry workers in Germany found bones in a cave which seemed to belong to a bear or other large mammal. They were later identified as being from a previously unknown species of hominid similar to a human. The specimen was named Homo neanderthalis after the valley in which the bones were found.This was the first identified remains of a Neanderthal, a species which inhabited parts of Europe and Central Asia from around 400,000 years ago. Often depicted as little more advanced than apes, Neanderthals were in fact sophisticated, highly-evolved hunters capable of making tools and even jewellery.Scholarship has established much about how and where the Neanderthals lived - but the reasons for their disappearance from the planet around 28,000 years ago remain unclear.With: Simon Conway MorrisProfessor of Evolutionary Palaeobiology at the University of CambridgeChris Stringer Research Leader in Human Origins at the Natural History Museum and Visiting Profes

From the 1600s to the 1800s, scientific research in Britain was not yet a professional, publicly-funded career.So the wealth, status and freedom enjoyed by British aristocrats gave them the opportunity to play an important role in pushing science forwards - whether as patrons or practitioners.The Cavendish family produced a whole succession of such figures.In the 1600s, the mathematician Sir Charles Cavendish and his brother William collected telescopes and mathematical treatises, and promoted dialogue between British and Continental thinkers. They brought Margaret Cavendish, William's second wife, into their discussions and researches, and she went on to become a visionary, if eccentric, science writer, unafraid to take on towering figures of the day like Robert Hooke.In the 1700s, the brothers' cousin's great-grandson, Lord Charles Cavendish, emerged as a leading light of the Royal Society.Underpinned by his rich inheritance, Charles' son Henry became one of the great experimental scientists of the English

The Cool Universe is the name astronomers give to the matter between the stars.These great clouds of dust and gas are not hot enough to be detected by optical telescopes.But over the last few decades, they have increasingly become the focus of infrared telescopy.Astronomers had long encountered dark, apparently starless patches in the night sky. When they discovered that these were actually areas obscured by dust, they found a way to see through these vexing barriers, using infrared telescopes, to the light beyond.However, more recently, the dust itself has become a source of fascination.The picture now being revealed by infrared astronomy is of a universe that is dynamic.In this dynamic universe, matter is recycled - and so the dust and gas of the Cool Universe play a vital role. They are the material from which the stars are created, and into which they finally disintegrate, enriching the reservoir of cool matter from which new stars will eventually be formed. As a result of the new research, we are now beg

Melvyn Bragg and guests Usha Goswami, Annette Karmiloff-Smith and Denis Mareschal discuss what new research reveals about the infant brain.For obvious reasons, what happens in the minds of very young, pre-verbal children is elusive. But over the last century, the psychology of early childhood has become a major subject of study. Some scientists and researchers have argued that children develop skills only gradually, others that many of our mental attributes are innate. Sigmund Freud concluded that infants didn't differentiate themselves from their environment. The pioneering Swiss child psychologist Jean Piaget thought babies' perception of the world began as a 'blooming, buzzing confusion' of colour, light and sound, before they developed a more sophisticated worldview, first through the senses and later through symbol. More recent scholars such as the leading American theoretical linguist Noam Chomsky have argued that the fundamentals of language are there from birth. Chomsky has famously argued that al

Melvyn Bragg and guests John Barrow, Colva Roney-Dougal and Marcus du Sautoy explore the unintended consequences of mathematical discoveries, from the computer to online encryption, to alternating current and predicting the path of asteroids.In his book The Mathematician's Apology (1941), the Cambridge mathematician GH Hardy expressed his reverence for pure maths, and celebrated its uselessness in the real world. Yet one of the branches of pure mathematics in which Hardy excelled was number theory, and it was this field which played a major role in the work of his younger colleague, Alan Turing, as he worked first to crack Nazi codes at Bletchley Park and then on one of the first computers.Melvyn Bragg and guests explore the many surprising and completely unintended uses to which mathematical discoveries have been put. These include:The cubic equations which led, after 400 years, to the development of alternating current - and the electric chair.The centuries-old work on games of chance which eventually cont

As part of the BBC's year of science programming, Melvyn Bragg looks at the history of the oldest scientific learned society of them all: the Royal Society. The horrors of the First World War were a shocking indictment of the power of science. Picking up the thread at this hiatus in scientific optimism, this programme, recorded in the current home of the Royal Society in Carlton House Terrace in London, looks at the more subtle, discreet role the Society played in the 20th century, such as secretly arranging for refugee scientists to flee Germany, co-ordinating international scientific missions during the Cold War and quietly distributing government grant money to fund the brightest young researchers in the land. As ever more important scientific issues face the world and Britain today, the programme asks how well placed the Royal Society is to take an important lead in the future.

As part of the BBC's year of science programming, Melvyn Bragg looks at the history of the oldest scientific learned society of them all: the Royal Society. The 19th century blooms scientifically with numerous alternative, specialist learned societies and associations, all threatening the Royal Society's pre-eminence. Attempts to reform the membership criteria - marking scientific leadership's painful transition from patronage to expertise - are troubled, and organisations such as the British Association for the Advancement of Science (now the BSA) excite and enliven scientific discourse outside of London. Science becomes a realistic career and a path of improvement, and by the time HG Wells writes science fiction at the end of the 19th century, there are sufficient numbers of interested, informed readers to suggest that Edwardian society contained the beginnings of a scientific society.

As part of the BBC's year of science programming, Melvyn Bragg looks at the history of the oldest scientific learned society of them all: the Royal Society. Programme two begins in the coffee house Isaac Newton and the fellows of the early 18th century frequented. At the Royal Observatory, Greenwich, we learn how Newton's feud with the Astronomer Royal John Flamsteed tested the lines between government-funded research and public access. In the age of exploration, senior fellows accompany naval expeditions, such as Cook's expedition to Tahiti and subsequent discovery of Australia. International relations are fostered between scientists such as Benjamin Franklin, whose house in London serves as live-in lab and de facto American embassy. By the end of the century the President, Sir Joseph Banks, successfully embeds the Royal Society in the imperial bureaucratic hub of the new Somerset House. But while senior fellows concentrated on foreign fields, a more radical, dissident science and manufacturing base wrought