In Our Time: Science

Melvyn Bragg and guests discuss the life and work of Louis Pasteur (1822-1895) and his extraordinary contribution to medicine and science. It is said few people have saved more lives than Pasteur. A chemist, he showed that otherwise identical molecules could exist as 'left' and 'right-handed' versions and that molecules produced by living things were always left-handed. He proposed a germ theory to replace the idea of spontaneous generation. He discovered that microorganisms cause fermentation and disease. He began the process named after him, pasteurisation, heating liquids to 50-60 C to kill microbes. He saved the beer and wine industries in France when they were struggling with microbial contamination. He saved the French silk industry when he found a way of protecting healthy silkworm eggs from disease. He developed vaccines against anthrax and rabies and helped establish immunology. Many of his ideas were developed further after his lifetime, but one of his legacies was a charitable body, the Pasteur Ins

Melvyn Bragg and guests discuss the life and ideas of Wolfgang Pauli (1900-1958), whose Exclusion Principle is one of the key ideas in quantum mechanics. A brilliant physicist, at 21 Pauli wrote a review of Einstein's theory of general relativity and that review is still a standard work of reference today. The Pauli Exclusion Principle proposes that no two electrons in an atom can be at the same time in the same state or configuration, and it helps explain a wide range of phenomena such as the electron shell structure of atoms. Pauli went on to postulate the existence of the neutrino, which was confirmed in his lifetime. Following further development of his exclusion principle, Pauli was awarded the Nobel Prize in Physics in 1945 for his 'decisive contribution through his discovery of a new law of Nature'. He also had a long correspondence with Jung, and a reputation for accidentally breaking experimental equipment which was dubbed The Pauli Effect.With Frank Close Fellow Emeritus at Exeter College, Universit

Melvyn Bragg and guests discuss the high temperatures that marked the end of the Paleocene and start of the Eocene periods, about 50m years ago. Over c1000 years, global temperatures rose more than 5 C on average and stayed that way for c100,000 years more, with the surface of seas in the Arctic being as warm as those in the subtropics. There were widespread extinctions, changes in ocean currents, and there was much less oxygen in the sea depths. The rise has been attributed to an increase of carbon dioxide and methane in the atmosphere, though it is not yet known conclusively what the source of those gases was. One theory is that a rise in carbon dioxide, perhaps from volcanoes, warmed up the globe enough for warm water to reach the bottom of the oceans and so release methane from frozen crystals in the sea bed. The higher the temperature rose and the longer the water was warm, the more methane was released. Scientists have been studying a range of sources from this long period, from ice samples to fossils,

Melvyn Bragg and guests discuss the Kuiper Belt, a vast region of icy objects at the fringes of our Solar System, beyond Neptune, in which we find the dwarf planet Pluto and countless objects left over from the origins of the solar system, some of which we observe as comets. It extends from where Neptune is, which is 30 times further out than the Earth is from the Sun, to about 500 times the Earth-Sun distance. It covers an immense region of space and it is the part of the Solar System that we know the least about, because it is so remote from us and has been barely detectable by Earth-based telescopes until recent decades. Its existence was predicted before it was known, and study of the Kuiper Belt, and how objects move within it, has led to a theory that there may be a 9th planet far beyond Neptune.WithCarolin Crawford Public Astronomer at the Institute of Astronomy and Fellow of Emmanuel College, University of CambridgeMonica Grady Professor of Planetary and Space Sciences at the Open UniversityAndStephen

Melvyn Bragg and guests discuss the flourishing of maths in the early Islamic world, as thinkers from across the region developed ideas in places such as Baghdad's House of Wisdom. Among them were the Persians Omar Khayyam, who worked on equations, and Al-Khwarizmi, latinised as Algoritmi and pictured above, who is credited as one of the fathers of algebra, and the Jewish scholar Al-Samawal, who converted to Islam and worked on mathematical induction. As well as the new ideas, there were many advances drawing on Indian, Babylonian and Greek work and, thanks to the recording or reworking by mathematicians in the Islamic world, that broad range of earlier maths was passed on to western Europe for further study.With Colva Roney-Dougal Reader in Pure Mathematics at the University of St AndrewsPeter Pormann Professor of Classics & Graeco-Arabic Studies at the University of ManchesterAndJim Al-Khalili Professor of Physics at the University of SurreyProducer: Simon Tillotson.

Melvyn Bragg and guests discuss the relationship between parasites and hosts, where one species lives on or in another to the benefit of the parasite but at a cost to the host, potentially leading to disease or death of the host. Typical examples are mistletoe and trees, hookworms and vertebrates, cuckoos and other birds. In many cases the parasite species do so well in or on a particular host that they reproduce much faster and can adapt to changes more efficiently, and it is thought that almost half of all animal species have a parasitic stage in their lifetime. What techniques do hosts have to counter the parasites, and what impact do parasites have on the evolution of their hosts? With Steve Jones Emeritus Professor of Genetics at University College, LondonWendy Gibson Professor of Protozoology at the University of Bristoland Kayla King Associate Professor in the Department of Zoology at the University of OxfordProducer: Simon Tillotson.

Melvyn Bragg and guests discuss the German astronomer Johannes Kepler (1571 - 1630). Although he is overshadowed today by Isaac Newton and Galileo, he is considered by many to be one of the greatest scientists in history. The three laws of planetary motion Kepler developed transformed people's understanding of the Solar System and laid the foundations for the revolutionary ideas Isaac Newton produced later. Kepler is also thought to have written one of the first works of science fiction. However, he faced a number of challenges. He had to defend his mother from charges of witchcraft, he had few financial resources and his career suffered as a result of his Lutheran faith. With David Wootton Professor of History at the University of YorkUlinka Rublack Professor of Early Modern European History at the University of Cambridge and Fellow of St John's CollegeAdam Mosley Associate Professor in the Department of History at Swansea University Producer: Victoria Brignell.

The scientist John Dalton was born in North England in 1766. Although he came from a relatively poor Quaker family, he managed to become one of the most celebrated scientists of his age. Through his work, he helped to establish Manchester as a place where not only products were made but ideas were born. His reputation during his lifetime was so high that unusually a statue was erected to him before he died. Among his interests were meteorology, gasses and colour blindness. However, he is most remembered today for his pioneering thinking in the field of atomic theory. With: Jim Bennett Former Director of the Museum of the History of Science at the University of Oxford and Keeper Emeritus at the Science MuseumAileen Fyfe Reader in British History at the University of St AndrewsJames Sumner Lecturer in the History of Technology at the Centre for the History of Science, Technology and Medicine at the University of ManchesterProducer: Victoria Brignell.

Melvyn Bragg and guests discuss plasma, the fourth state of matter after solid, liquid and gas. As over ninety-nine percent of all observable matter in the Universe is plasma, planets like ours, with so little plasma and so much solid, liquid and gas, appear all the more remarkable. On the grand scale, plasma is what the Sun is made from and, when we look into the night sky, almost everything we can see with the naked eye is made of plasma. On the smallest scale, here on Earth, scientists make plasma to etch the microchips on which we rely for so much. Plasma is in the fluorescent light bulbs above our heads and, in laboratories around the world, it is the subject of tests to create, one day, an inexhaustible and clean source of energy from nuclear fusion.With Justin Wark Professor of Physics and Fellow of Trinity College at the University of OxfordKate Lancaster Research Fellow for Innovation and Impact at the York Plasma Institute at the University of Yorkand Bill Graham Professor of Physics at Queens Unive

In a programme first broadcast in 2016, Melvyn Bragg and guests discuss Zeno of Elea, a pre-Socratic philosopher from c490-430 BC whose paradoxes were described by Bertrand Russell as "immeasurably subtle and profound." The best known argue against motion, such as that of an arrow in flight which is at a series of different points but moving at none of them, or that of Achilles who, despite being the faster runner, will never catch up with a tortoise with a head start. Aristotle and Aquinas engaged with these, as did Russell, yet it is still debatable whether Zeno's Paradoxes have been resolved.With Marcus du Sautoy Professor of Mathematics and Simonyi Professor for the Public Understanding of Science at the University of OxfordBarbara Sattler Lecturer in Philosophy at the University of St Andrewsand James Warren Reader in Ancient Philosophy at the University of CambridgeProducer: Simon Tillotson

Melvyn Bragg and guests discuss the development of photography in the 1830s, when techniques for 'drawing with light' evolved to the stage where, in 1839, both Louis Daguerre and William Henry Fox Talbot made claims for its invention. These followed the development of the camera obscura, and experiments by such as Thomas Wedgwood and Nicéphore Niépce, and led to rapid changes in the 1840s as more people captured images with the daguerreotype and calotype. These new techniques changed the aesthetics of the age and, before long, inspired claims that painting was now dead.WithSimon Schaffer Professor of the History of Science at the University of CambridgeElizabeth Edwards Emeritus Professor of Photographic History at De Montfort UniversityAndAlison Morrison-Low, Research Associate at National Museums ScotlandProducer: Simon Tillotson.

Melvyn Bragg and guests discuss penicillin, discovered by Alexander Fleming in 1928. It is said he noticed some blue-green penicillium mould on an uncovered petri dish at his hospital laboratory, and that this mould had inhibited bacterial growth around it. After further work, Fleming filtered a broth of the mould and called that penicillin, hoping it would be useful as a disinfectant. Howard Florey and Ernst Chain later shared a Nobel Prize in Medicine with Fleming, for their role in developing a way of mass-producing the life-saving drug. Evolutionary theory predicted the risk of resistance from the start and, almost from the beginning of this 'golden age' of antibacterials, scientists have been looking for ways to extend the lifespan of antibiotics.WithLaura Piddock Professor of Microbiology at the University of BirminghamChristoph Tang Professor of Cellular Pathology and Professorial Fellow at Exeter College at the University of OxfordAndSteve Jones Emeritus Professor of Genetics at University College, Lo

Melvyn Bragg and guests discuss Euclid's Elements, a mathematical text book attributed to Euclid and in use from its appearance in Alexandria, Egypt around 300 BC until modern times, dealing with geometry and number theory. It has been described as the most influential text book ever written. Einstein had a copy as a child, which he treasured, later saying "If Euclid failed to kindle your youthful enthusiasm, then you were not born to be a scientific thinker."With Marcus du Sautoy Professor of Mathematics and Simonyi Professor for the Public Understanding of Science at the University of OxfordSerafina Cuomo Reader in Roman History at Birkbeck University of LondonAnd June Barrow-Green Professor of the History of Mathematics at the Open UniversityProducer: Simon Tillotson.

Melvyn Bragg and guests discuss the impact of the eruption of Mt Tambora, in 1815, on the Indonesian island of Sambawa. This was the largest volcanic eruption in recorded history and it had the highest death toll, devastating people living in the immediate area. Tambora has been linked with drastic weather changes in North America and Europe the following year, with frosts in June and heavy rains throughout the summer in many areas. This led to food shortages, which may have prompted westward migration in America and, in a Europe barely recovered from the Napoleonic Wars, led to widespread famine. With Clive Oppenheimer Professor of Volcanology at the University of CambridgeJane Stabler Professor in Romantic Literature at the University of St AndrewsAndLawrence Goldman Director of the Institute of Historical Research at the University of LondonProducer: Simon Tillotson.

Melvyn Bragg and guests discuss the neutron, one of the particles found in an atom's nucleus. Building on the work of Ernest Rutherford, the British physicist James Chadwick won the Nobel Prize for Physics for his discovery of the neutron in 1932. Neutrons play a fundamental role in the universe and their discovery was at the heart of developments in nuclear physics in the first half of the 20th century. With Val Gibson Professor of High Energy Physics at the University of Cambridge and fellow of Trinity CollegeAndrew Harrison Chief Executive Officer of Diamond Light Source and Professor in Chemistry at the University of EdinburghAndFrank Close Professor Emeritus of Physics at the University of Oxford.

Melvyn Bragg and guests discuss the life and work of Robert Hooke (1635-1703) who worked for Robert Boyle and was curator of experiments at the Royal Society. The engraving of a flea, above, is taken from his Micrographia which caused a sensation when published in 1665. Sometimes remembered for his disputes with Newton, he studied the planets with telescopes and snowflakes with microscopes. He was an early proposer of a theory of evolution, discovered light diffraction with a wave theory to explain it and felt he was rarely given due credit for his discoveries. WithDavid Wootton Anniversary Professor of History at the University of YorkPatricia Fara President Elect of the British Society for the History of ScienceAndRob Iliffe Professor of History of Science at Oxford UniversityProducer: Simon Tillotson.

Melvyn Bragg and guests discuss the origins, development and uses of chromatography. In its basic form, it is familiar to generations of schoolchildren who put a spot of ink at the bottom of a strip of paper, dip it in water and then watch the pigments spread upwards, revealing their separate colours. Chemists in the 19th Century started to find new ways to separate mixtures and their work was taken further by Mikhail Tsvet, a Russian-Italian scientist who is often credited with inventing chromatography in 1900. The technique has become so widely used, it is now an integral part of testing the quality of air and water, the levels of drugs in athletes, in forensics and in the preparation of pharmaceuticals.WithAndrea Sella Professor of Chemistry at University College LondonApryll Stalcup Professor of Chemical Sciences at Dublin City UniversityAndLeon Barron Senior Lecturer in Forensic Science at King's College London.

Melvyn Bragg and guests discuss the planet Saturn with its rings of ice and rock and over 60 moons. In 1610, Galileo used an early telescope to observe Saturn, one of the brightest points in the night sky, but could not make sense of what he saw: perhaps two large moons on either side. When he looked a few years later, those supposed moons had disappeared. It was another forty years before Dutch scientist Christiaan Huygens solved the mystery, realizing the moons were really a system of rings. Successive astronomers added more detail, with the greatest leaps forward in the last forty years. The Pioneer 11 spacecraft and two Voyager missions have flown by, sending back the first close-up images, and Cassini is still there, in orbit, confirming Saturn, with its rings and many moons, as one of the most intriguing and beautiful planets in our Solar System. WithCarolin Crawford Public Astronomer at the Institute of Astronomy and Fellow of Emmanuel College, University of CambridgeMichele Dougherty Professor of Spac

Melvyn Bragg and guests discuss the eminent 19th-century scientist Michael Faraday. Born into a poor working-class family, he received little formal schooling but became interested in science while working as a bookbinder's apprentice. He is celebrated today for carrying out pioneering research into the relationship between electricity and magnetism. Faraday showed that if a wire was turned in the presence of a magnet or a magnet was turned in relation to a wire, an electric current was generated. This ground-breaking discovery led to the development of the electric generator and ultimately to modern power stations. During his life he became the most famous scientist in Britain and he played a key role in founding the Royal Institution's Christmas lectures which continue today.With:Geoffrey Cantor Professor Emeritus of the History of Science at the University of LeedsLaura Herz Professor of Physics at the University of OxfordFrank James Professor of the History of Science at the Royal InstitutionProducer: Vic

Melvyn Bragg and his guests discuss the evolution and role of Circadian Rhythms, the so-called body clock that influences an organism's daily cycle of physical, behavioural and mental changes. The rhythms are generated within organisms and also in response to external stimuli, mainly light and darkness. They are found throughout the living world, from bacteria to plants, fungi to animals and, in humans, are noticed most clearly in sleep patterns. WithRussell Foster Professor of Circadian Neuroscience at the University of OxfordDebra Skene Professor of Neuroendocrinology at the University of SurreyAndSteve Jones Emeritus Professor of Genetics at University College London.