In Our Time: Science

Melvyn Bragg and guests discuss what happens when parents from different species have offspring, despite their genetic differences. In some cases, such as the zebra/donkey hybrid in the image above, the offspring are usually infertile but in others the genetic change can lead to new species with evolutionary advantages. Hybrids can occur naturally, yet most arise from human manipulation and Darwin's study of plant and animal domestication informed his ideas on natural selection.With Sandra Knapp Tropical Botanist at the Natural History MuseumNicola Nadeau Lecturer in Evolutionary Biology at the University of SheffieldAndSteve Jones Senior Research Fellow in Genetics at University College LondonProducer: Simon Tillotson

Melvyn Bragg and guests discuss the work and ideas of Dorothy Crowfoot Hodgkin (1910-1994), awarded the Nobel Prize in Chemistry in 1964 for revealing the structures of vitamin B12 and penicillin and who later determined the structure of insulin. She was one of the pioneers of X-ray crystallography and described by a colleague as 'a crystallographers' crystallographer'. She remains the only British woman to have won a Nobel in science, yet rejected the idea that she was a role model for other women, or that her career was held back because she was a woman. She was also the first woman since Florence Nightingale to receive the Order of Merit, and was given the Lenin Peace Prize in recognition of her efforts to bring together scientists from the East and West in pursuit of nuclear disarmament.With Georgina Ferry Science writer and biographer of Dorothy HodgkinJudith Howard Professor of Chemistry at Durham UniversityandPatricia Fara Fellow of Clare College, CambridgeProducer: Simon Tillotson

Melvyn Bragg and guests discuss how scientists sought to understand the properties of gases and the relationship between pressure and volume, and what that search unlocked. Newton theorised that there were static particles in gases that pushed against each other all the harder when volume decreased, hence the increase in pressure. Those who argued that molecules moved, and hit each other, were discredited until James Maxwell and Ludwig Boltzmann used statistics to support this kinetic theory. Ideas about atoms developed in tandem with this, and it came as a surprise to scientists in C20th that the molecules underpinning the theory actually existed and were not simply thought experiments. The image above is of Ludwig Boltzmann from a lithograph by Rudolf Fenzl, 1898With Steven Bramwell Professor of Physics at University College LondonIsobel Falconer Reader in History of Mathematics at the University of St Andrewsand Ted Forgan Emeritus Professor of Physics at the University of BirminghamProducer: Simon Tillot

Melvyn Bragg and guests discuss theories about the origins of teeth in vertebrates, and what we can learn from sharks in particular and their ancestors. Great white sharks can produce up to 100,000 teeth in their lifetimes. For humans, it is closer to a mere 50 and most of those have to last from childhood. Looking back half a billion years, though, the ancestors of sharks and humans had no teeth in their mouths at all, nor jaws. They were armoured fish, sucking in their food. The theory is that either their tooth-like scales began to appear in mouths as teeth, or some of their taste buds became harder. If we knew more about that, and why sharks can regenerate their teeth, then we might learn how humans could grow new teeth in later lives. With Gareth Fraser Assistant Professor in Biology at the University of FloridaZerina Johanson Merit Researcher in the Department of Earth Sciences at the Natural History Museumand Philip Donoghue Professor of Palaeobiology at the University of BristolProducer: Simon Ti

Melvyn Bragg and guests discuss how members of the same species send each other invisible chemical signals to influence the way they behave. Pheromones are used by species across the animal kingdom in a variety of ways, such as laying trails to be followed, to raise the alarm, to scatter from predators, to signal dominance and to enhance attractiveness and, in honey bees, even direct development into queen or worker. The image above is of male and female ladybirds that have clustered together in response to pheromones. With Tristram Wyatt Senior Research Fellow at the Department of Zoology at the University of OxfordJane Hurst William Prescott Professor of Animal Science at the University of Liverpooland Francis Ratnieks Professor of Apiculture and Head of the Laboratory of Apiculture and Social Insects at the University of SussexProducer: Simon Tillotson

Melvyn Bragg and guests discuss the remarkable achievement of Aristotle (384-322BC) in the realm of biological investigation, for which he has been called the originator of the scientific study of life. Known mainly as a philosopher and the tutor for Alexander the Great, who reportedly sent him animal specimens from his conquests, Aristotle examined a wide range of life forms while by the Sea of Marmara and then on the island of Lesbos. Some ideas, such as the the spontaneous generation of flies, did not survive later scrutiny, yet his influence was extraordinary and his work was unequalled until the early modern period.The image above is of the egg and embryo of a dogfish, one of the animals Aristotle described accurately as he recorded their development.WithArmand Leroi Professor of Evolutionary Development Biology at Imperial College LondonMyrto Hatzimichali Lecturer in Classics at the University of CambridgeAndSophia Connell Lecturer in Philosophy at Birkbeck, University of LondonProducer: Simon Tillots

Melvyn Bragg and guests discuss the ideas and life of one of the greatest mathematicians of the 20th century, Emmy Noether. Noether’s Theorem is regarded as one of the most important mathematical theorems, influencing the evolution of modern physics. Born in 1882 in Bavaria, Noether studied mathematics at a time when women were generally denied the chance to pursue academic careers and, to get round objections, she spent four years lecturing under a male colleague’s name. In the 1930s she faced further objections to her teaching, as she was Jewish, and she left for the USA when the Nazis came to power. Her innovative ideas were to become widely recognised and she is now considered to be one of the founders of modern algebra.With Colva Roney Dougal Professor of Pure Mathematics at the University of St AndrewsDavid Berman Professor in Theoretical Physics at Queen Mary, University of LondonElizabeth Mansfield Professor of Mathematics at the University of Kent Producer: Simon Tillotson

Melvyn Bragg and guests discuss the planet Venus which is both the morning star and the evening star, rotates backwards at walking speed and has a day which is longer than its year. It has long been called Earth’s twin, yet the differences are more striking than the similarities. Once imagined covered with steaming jungles and oceans, we now know the surface of Venus is 450 degrees celsius, and the pressure there is 90 times greater than on Earth, enough to crush an astronaut. The more we learn of it, though, the more we learn of our own planet, such as whether Earth could become more like Venus in some ways, over time. WithCarolin Crawford Public Astronomer at the Institute of Astronomy and Fellow of Emmanuel College, University of CambridgeColin Wilson Senior Research Fellow in Planetary Science at the University of OxfordAnd Andrew Coates Professor of Physics at Mullard Space Science Laboratory, University College LondonProduced by: Simon Tillotson and Julia Johnson

Melvyn Bragg and guests discuss the properties of atoms or molecules with a single unpaired electron, which tend to be more reactive, keen to seize an electron to make it a pair. In the atmosphere, they are linked to reactions such as rusting. Free radicals came to prominence in the 1950s with the discovery that radiation poisoning operates through free radicals, as it splits water molecules and produces a very reactive hydroxyl radical which damages DNA and other molecules in the cell. There is also an argument that free radicals are a byproduct of normal respiration and over time they cause an accumulation of damage that is effectively the process of ageing. For all their negative associations, free radicals play an important role in signalling and are also linked with driving cell division, both cancer and normal cell division, even if they tend to become damaging when there are too many of them.With Nick Lane Professor of Evolutionary Biochemistry at University College LondonAnna Croft Associate Professor

Melvyn Bragg and guests discuss the history of real and imagined machines that appear to be living, and the questions they raise about life and creation. Even in myth they are made by humans, not born. The classical Greeks built some and designed others, but the knowledge of how to make automata and the principles behind them was lost in the Latin Christian West, remaining in the Greek-speaking and Arabic-speaking world. Western travellers to those regions struggled to explain what they saw, attributing magical powers. The advance of clockwork raised further questions about what was distinctly human, prompting Hobbes to argue that humans were sophisticated machines, an argument explored in the Enlightenment and beyond.The image above is Jacques de Vaucanson's mechanical duck (1739), which picked up grain, digested and expelled it. If it looks like a duck...with Simon Schaffer Professor of History of Science at Cambridge UniversityElly Truitt Associate Professor of Medieval History at Bryn Mawr CollegeAnd Fran

Melvyn Bragg and guests discuss how some bats, dolphins and other animals emit sounds at high frequencies to explore their environments, rather than sight. This was such an unlikely possibility, to natural historians from C18th onwards, that discoveries were met with disbelief even into the C20th; it was assumed that bats found their way in the dark by touch. Not all bats use echolocation, but those that do have a range of frequencies for different purposes and techniques for preventing themselves becoming deafened by their own sounds. Some prey have evolved ways of detecting when bats are emitting high frequencies in their direction, and some fish have adapted to detect the sounds dolphins use to find them. With Kate Jones Professor of Ecology and Biodiversity at University College LondonGareth Jones Professor of Biological Sciences at the University of BristolAndDean Waters Lecturer in the Environment Department at the University of YorkProducer: Simon Tillotson.

Melvyn Bragg and guests discuss the discovery and growing understanding of the Proton, formed from three quarks close to the Big Bang and found in the nuclei of all elements. The positive charges they emit means they attract the fundamental particles of negatively charged electrons, an attraction that leads to the creation of atoms which in turn leads to chemistry, biology and life itself. The Sun (in common with other stars) is a fusion engine that turn protons by a series of processes into helium, emitting energy in the process, with about half of the Sun's protons captured so far. Hydrogen atoms, stripped of electrons, are single protons which can be accelerated to smash other nuclei and have applications in proton therapy. Many questions remain, such as why are electrical charges for protons and electrons so perfectly balanced?WithFrank Close Professor Emeritus of Physics at the University of OxfordHelen Heath Reader in Physics at the University of BristolAndSimon Jolly Lecturer in High Energy Physics at

In a programme first broadcast on April 12th 2018, Melvyn Bragg and guests discuss the contribution of George Stephenson (1781-1848) and his son Robert (1803-59) to the development of the railways in C19th. George became known as The Father of Railways and yet arguably Robert's contribution was even greater, with his engineering work going far beyond their collaboration. Robert is credited with the main role in the design of their locomotives. George had worked on stationary colliery steam engines and, with Robert, developed the moving steam engine Locomotion No1 for the Stockton and Darlington Railway in 1825. They produced the Rocket for the Rainhill Trials on the Liverpool and Manchester Railway in 1829. From there, the success of their designs and engineering led to the expansion of railways across Britain and around the world. with Dr Michael Bailey Railway historian and editor of the most recent biography of Robert StephensonJulia Elton Past President of the Newcomen Society for the History of Engineeri

Melvyn Bragg and guests discuss the pioneering scientist Rosalind Franklin (1920 - 1958). During her distinguished career, Franklin carried out ground-breaking research into coal and viruses but she is perhaps best remembered for her investigations in the field of DNA. In 1952 her research generated a famous image that became known as Photograph 51. When the Cambridge scientists Francis Crick and James Watson saw this image, it enabled them the following year to work out that DNA has a double-helix structure, one of the most important discoveries of modern science. Watson, Crick and Franklin's colleague Maurice Wilkins received a Nobel Prize in 1962 for this achievement but Franklin did not and today many people believe that Franklin has not received enough recognition for her work. With:Patricia Fara President of the British Society for the History of ScienceJim Naismith Interim lead of the Rosalind Franklin Institute, Director of the Research Complex at Harwell and Professor at the University of OxfordJudit

Melvyn Bragg and guests discuss fungi. These organisms are not plants or animals but a kingdom of their own. Millions of species of fungi live on the Earth and they play a crucial role in ecosystems, enabling plants to obtain nutrients and causing material to decay. Without fungi, life as we know it simply would not exist. They are also a significant part of our daily life, making possible the production of bread, wine and certain antibiotics. Although fungi brought about the colonisation of the planet by plants about 450 million years ago, some species can kill humans and devastate trees. With:Lynne Boddy Professor of Fungal Ecology at Cardiff UniversitySarah Gurr Professor of Food Security in the Biosciences Department at the University of ExeterDavid Johnson N8 Chair in Microbial Ecology at the University of ManchesterProducer: Victoria Brignell.

The octopus, the squid, the nautilus and the cuttlefish are some of the most extraordinary creatures on this planet, intelligent and yet apparently unlike other life forms. They are cephalopods and are part of the mollusc family like snails and clams, and they have some characteristics in common with those. What sets them apart is the way members of their group can change colour, camouflage themselves, recognise people, solve problems, squirt ink, power themselves with jet propulsion and survive both on land, briefly, and in the deepest, coldest oceans. And, without bones or shells, they grow so rapidly they can outstrip their rivals when habitats change, making them the great survivors and adaptors of the animal world.WithLouise Allcock Lecturer in Zoology at the National University of Ireland, GalwayPaul Rodhouse Emeritus Fellow of the British Antarctic SurveyandJonathan Ablett Senior Curator of Molluscs at the Natural History MuseumProducer: Simon Tillotson.

In a programme first broadcast in 2017, Melvyn Bragg and guests discuss Gauss (1777-1855), widely viewed as one of the greatest mathematicians of all time. He was a child prodigy, correcting his father's accounts before he was 3, dumbfounding his teachers with the speed of his mental arithmetic, and gaining a wealthy patron who supported his education. He wrote on number theory when he was 21, with his Disquisitiones Arithmeticae, which has influenced developments since. Among his achievements, he was the first to work out how to make a 17-sided polygon, he predicted the orbit of the minor planet Ceres, rediscovering it, he found a way of sending signals along a wire, using electromagnetism, the first electromagnetic telegraph, and he advanced the understanding of parallel lines on curved surfaces. With Marcus du Sautoy Professor of Mathematics and Simonyi Professor for the Public Understanding of Science at the University of OxfordColva Roney-Dougal Reader in Pure Mathematics at the University of St AndrewsA

In a programme first broadcast in 2017, Melvyn Bragg and guests discuss the development of theories about dinosaur feathers, following discoveries of fossils which show evidence of feathers. All dinosaurs were originally thought to be related to lizards - the word 'dinosaur' was created from the Greek for 'terrible lizard' - but that now appears false. In the last century, discoveries of fossils with feathers established that at least some dinosaurs were feathered and that some of those survived the great extinctions and evolved into the birds we see today. There are still many outstanding areas for study, such as what sorts of feathers they were, where on the body they were found, what their purpose was and which dinosaurs had them. With Mike Benton Professor of Vertebrate Palaeontology at the University of BristolSteve Brusatte Reader and Chancellor's Fellow in Vertebrate Palaeontology at the University of EdinburghandMaria McNamara Senior Lecturer in Geology at University College, CorkProducer: Simon Tillo

In a programme first broadcast in 2017, Melvyn Bragg and guests discuss why some birds migrate and others do not, how they select their destinations and how they navigate the great distances, often over oceans. For millennia, humans set their calendars to birds' annual arrivals, and speculated about what happened when they departed, perhaps moving deep under water, or turning into fish or shellfish, or hibernating while clinging to trees upside down. Ideas about migration developed in C19th when, in Germany, a stork was noticed with an African spear in its neck, indicating where it had been over the winter and how far it had flown. Today there are many ideas about how birds use their senses of sight and smell, and magnetic fields, to find their way, and about why and how birds choose their destinations and many questions. Why do some scatter and some flock together, how much is instinctive and how much is learned, and how far do the benefits the migrating birds gain outweigh the risks they face?With Barbara H

Melvyn Bragg and guests discuss enzymes, the proteins that control the speed of chemical reactions in living organisms. Without enzymes, these reactions would take place too slowly to keep organisms alive: with their actions as catalysts, changes which might otherwise take millions of years can happen hundreds of times a second. Some enzymes break down large molecules into smaller ones, like the ones in human intestines, while others use small molecules to build up larger, complex ones, such as those that make DNA. Enzymes also help keep cell growth under control, by regulating the time for cells to live and their time to die, and provide a way for cells to communicate with each other. With Nigel Richards Professor of Biological Chemistry at Cardiff UniversitySarah Barry Lecturer in Chemical Biology at King's College LondonAnd Jim Naismith Director of the Research Complex at Harwell Bishop Wardlaw Professor of Chemical Biology at the University of St Andrews Professor of Structural Biology at the University o