Authentic Biochemistry

Clinical and Molecular Allergy volume 15, Article number: 21 (2017) Front. Immunol., 25 September 2019 | https://doi.org/10.3389/fimmu.2019.02247 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Oncotarget. 2013 Oct; 4(10): 1552–1553 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

In this episode Dr. Guerra provides the overview of Pharmacodynamics . --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

A.D.M.E. Anesthesiology Clinics, 2019-09-01, Volume 37, Issue 3, Pages 475-492. Please subscribe and donate! Dr. Guerra needs your support! --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Risk factors for aging morbidity are linked to large variations in protein synthesis and lack of adipose derived TAG utilization. The immune  response becomes compromised during aging leading to states of hyperinflammation followed by hypo-immune sequalae opening up the potential for opportunistic respiratory infections and alterations in pulmonary endothelial membrane lipid fluidity restricting oxygen intake. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Seminars in Cell & Developmental Biology Volume 40, April 2015, Pages 115-126 Pharmaceutical Research March 2018, 35:49 Journal of Molecular Endocrinology 2017. 58, 1; 10.1530/JME-16-0182 J. Lipid Res. 2018 59:(3) 488-506. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Feng, T., Yang, X., Hao, S. et al. Immunol Res. 05 April 2020 Molecular Neurodegeneration volume 7, Article number: 45 (2012) J Biol Chem. 2019 Jun 7;294(23):9213-9224 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Annu. Rev. Physiol. 2013. 75:685–705 Nutrients. 2020 Mar; 12(3): 622 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

FASEB J. 2013 Jun; 27(6): 2458–2467. Scientific Reports volume 7, Article number: 13763 (2017) --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Scientific Reports volume 9, Article number: 1220 (2019) Prog Neuropsychopharmacol Biol Psychiatry. 2005 Oct 12 Bulletin of Experimental Biology and Medicine.2003. 136.(3). 1573-8221  Pharmacological reports 2005, vol. 57, no6, pp. 811-817 Brain Res Bull, December 11, 2006; 71(1-3): 279-86. Journal of Endotoxin Research, Vol. 4, No. 5, 363-370 (1997) Scientific Reports volume 7, Article number: 13763 (2017) --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Brain Behav Immun. 2019 Oct;81:41-51 Neuroimmunomodulation 2002/2003;10:101-121 Front. Neurol., 23 January 2018 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

TLRs recognize molecular patterns associated with invasive pathogens. TIR domain-containing adaptors define the specificity of TLR signaling. TLR  interactions from CNS-resident microglia can obtain a pro-inflammatory environment that leads to neuronal degeneration as associated with classical aging related diseases like Parkinson's. J Neuroinflammation. 2014 Sep 20;11:166 Brain Behav Immun. 2019 Oct;81:41-51 J Mol Neurosci. 2021 Mar 9 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Pathogens, and abiotic ischaemic damage manifest a constellation of  molecular interactions triggering pattern recognition receptors such as TLR's, with canonical protein binding domains that signal through intracellular cascades such as activating  Ca2+ signaling; eo ipso obtaining potent hyperimmune inflammation,  providing  event ontological foundation and episodic contribution to the aging morbidity in human decline and mortality. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Oncotarget. 2016 Jan 26; 7(4): 4195–4209 Nature Reviews Immunology volume 6, pages644–658(2006) --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

The removal of damaged neurons and associated synaptic connections with the simultaneous repair of other neuronal circuits is a mechanism for the sculpting of the brain network and thus a means by which the highly innervated and connected prefrontal cortex can receive and respond to neurotransmission from the limbic system. Reference: Genes (Basel). 2019 Mar; 10(3): 249 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Authentic Biochemistry Podcast 27 April 2021 References Clin Diagn Lab Immunol. 2003 Jan;10(1):13-8 J Exp Med (2012) 209 (1): 187–199. Cell Reports 2020. V 30, (Issue 5) :1585-1597.e6 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

References Experimental & Molecular Medicine volume51, Article number: 80 (2019) Am J Nephrol.2017;46(5):371-379 EMBO Rep . 2003 Aug;4(8):774-80 J Biol Chem. 2020 Jul 3;295(27):9052-9060 Mol Immunol. 2017Aug;88:125-134 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

As an hypothetico-deduction,  Dr. Guerra proposes that the Recombination Activating Gene-RAG System is a Potential Candidate in Age Associated Morbidity. In conjunction with a neutral sphingomyelinase and the subsequent synthesis of diacylglycerol thence promoting activation of a PKC-Zeta, T cell receptor translocation and activation are obtained.  Prior RAG mediated recombination events in CNS-resident lymphocytes, associated microglia and neurons can lead to recombination event epigenomic ontologies that either promote or curtail a resident hyperimmune response   leading to classical neurodegenerative diseases of the elderly. References: J. Biol. Chem. 1998;273:14550-14559 Frontiers in Immunology.2014. 5:100 Front Cell Dev Biol. 2019; 7: 226. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Single-nucleotide polymorphisms and  copy-number variations (CNV’s)  result from genome wide chromosomal abnormalities including large deletions and duplications where the the immune system appears to play a major role in  the accumulation of chromosomal variation. Aging in humans may be linked to immune-mediated epigenomic epistasis as facilitated by Recombination Activating Gene proteins RAG1 & RAG2 that are canonically linked to V(D)J recombination of the T cell receptor and the B cell immunoglobulins. FEBS J. 2017 Jun; 284(11): 1590–1605. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Neuroinflammatory mediators play a critical role in the pathophysiology of brain ischemia, exerting either deleterious effects on the progression of tissue damage or beneficial roles during recovery and repair. These processes occur throughout life and involve the immune system, biochemical pathways, cellular turnover and alteration of gene expression. Signal transduction cascades allow for genome editing to epigenomic mediation of metabolic event ontologies. Aging is a process whereby these processes lose specificity and valence, increasingly functioning without appropriate fine control leading to the potential for chronic and more rarely, acute disease states that ultimately result in mortality --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message