A16z Podcast

In this hallway-style episode of the podcast, a16z partners Connie Chan and Kyle Russell discuss recent announcements at Facebook's annual developer conference, F8, in the context of trends such as: messaging and QR codes; brain computer interfaces; augmented reality and social VR; and, bots (again). As online platforms built on "real" identity and brands bring more of the real world into the digital realm, will we experience filter fatigue... or will the mundane become more profound? The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situatio

Is it real or science fiction to dream of being able to treat… getting old? In this episode, we discuss with Dr. Thomas Rando from Stanford (who directs the Glenn Center for the Biology of Aging), Kristen Fortney, CEO of BioAge, and a16z’s general partner Vijay Pande where we are in the field of “geroscience” — the idea of studying, well, aging itself, and aging as the root risk for all aging related disease. Far from science fiction, recent discoveries have given us a whole crop of promising breakthroughs to treat aging, such as parabiosis (young blood infused into old blood), senolytics, and rapamycin, and more. What we’re beginning to see is a fundamental shift away from the idea of searching for immortality and towards the idea of increasing "health span” — where prevention means much more than eating healthier or exercising more. Are we moving from Dx to Rx to — perhaps Px? What will it look like when anti-aging therapies actually begin to be delivered to us: small molecule or protein or an antibod

A crisis is an opportunity to change one's culture, to model scenarios and set up a crisis plan/process, to become a better company. But it's also a bit like therapy, from the act of asking probing questions to get at the facts ... to dealing with emotions and conflicting agendas. In this hallway-style conversation with a16z's Margit Wennmachers and Kim Milosevich -- who previously shared the why, how, and when of public relations -- we (with Sonal Chokshi) explore the process and mindsets behind the outcomes of a crisis in lieu of specific examples. Because it's something that seems so obvious to those who are on the inside (but even then it's really not!), yet is actually a bit of a "black box" to founders and others who aren’t familiar with crisis comms 101. What constitutes a crisis? Can someone inside a company "call it" early and prevent a crisis from becoming a bigger deal? How do you respond when there's a lag or too much time between acknowledging the issue and finding out all the

Here’s what we know about open source: Developers are the new buyers. Community matters. And there will never be another Red Hat (i.e., a successful “open core” business model … nor do we necessarily think there should be). Yet open source is real, and it’s here to stay. So how then do companies build a viable business model on top of open source? And not only make money, but become a huge business, like the IBMs, Microsofts, Oracles, and SAPs of the world? The answer, argues James Watters, has more to do with good software strategy and smart enterprise sales/procurement tactics (including design and a service-like experience) than with open source per se — from riding a huge trend or architectural shift, to being less transactional and more an extension of your customer’s team. Watters, who is the SVP of Product at Pivotal (part of VMWare and therefore also Dell-EMC), is a veteran of monetizing open source — from OpenSolaris (at Sun Microsystems) to Springsource (acquired by VMWare) to Pivotal Cloud Foundry

The culture of open source has changed across generations, from previous ones that had to fight for the brave new way -- to the current "GitHub generation" that not only accepts open source, but expects it as the default. Which makes sense given that open source powers so much of the software world today... and by the way, that's not just tech companies but hospitals and banks; it touches everyone. Open source culture has also moved away from cults of personality and top-down models to drive the vision for open source projects, to decentralized individual contributor identities and more micro-sized projects within projects. So what does that mean for the governance of open source, whether it's by institution or foundation, or a "healthy" or "popular" project? Should we invert, always invert to make sure open source code "lands" and is committed by default -- as opposed to going through a cabal of gatekeepers first? This episode of the a16z Podcast -- featuring Nadia Egh

Most of us have probably heard of bitcoin and ethereum -- but did you know there were 15 new cryptocurrencies launched this past month alone? How then do we know which protocols to invest in -- not just as a developer or user, but as an investor? Because, let's face it, open source software and services need resources not just to survive but thrive. General partner Chris Dixon talks about this dynamic between open vs closed in this episode of the a16z Podcast in conversation with Sonal Chokshi and with Olaf Carlson-Wee, founder of (a16z investment) Polychain, a new kind of hedge fund that invests directly in cryptocurrencies at the protocol layer. But what does that actually mean? Instead of investing in the companies that are building on top of these protocols, Polychain invests in the protocols themselves -- in much the same way that you could have invested in domain names instead of early internet companies like Amazon in the early days (which most people actually didn't have access to do). Imagine if you

In this episode of the a16z Podcast recorded at our inaugural Summit, Jonathan Downey, CEO of Airware, Grant Jordan, CEO of Skysafe, and Kyle Russell, partner at a16z, discuss our future with “eyes in the sky.” How do you balance experimentation and following the rules in a space where people have fears about what a future with drones might look like? This conversation covers the most interesting enterprise use cases for commercial drones, where we are in the introduction of drones into the consumer and commercial space (including the most interesting enterprise use cases for commercial drones), and how the industry will scale. Downey, Jordan, and Russell parse out what the new FAA regulation means big picture for drones and airspace, and what’s been overlooked. Regulation, says Grant, is just one element. What do we want our drone future to look like — where we want them flying and where we don't — and how will our responses to consumer and commercial drones affect each other? What are the privacy and safety

An aerospace engineer who worked for NASA for over 40 years, Dr. Christine Darden is one of the mathematicians that the book and movie Hidden Figures was based on. Darden eventually would lead the sonic boom team, going on to become the first African-American woman in senior management at NASA. In this intimate conversation with a16z’s general partner Jeff Jordan, held at the SF Jazz Center, Darden shares with Jordan how she first fell in love with geometry and math; the effect that Sputnik had on our culture (and her); and what it was like to work at NASA in the 1960s. And finally, Darden shares with us all the secrets of the sonic boom.

As we enter a new era of distributed computing -- and of big data, in the form of machine and deep learning -- storage becomes (even more) important. It might not be sexy, but storage is what makes the internet and cloud computing go round and round: "Without storage, we wouldn't have databases; without databases, we wouldn't have big data; we wouldn't have analytics ... we wouldn't have anything because information needs to be stored, and it needs to be retrieved." This is especially complicated by the fact that more and more computing is happening at the edge, as with autonomous car sensing. Clearly, storage is important. But now it's also undergoing a renaissance as it becomes faster, cheaper, and more in-memory. What does this mean for all the big players in the storage ecosystem? For CIOs and IT departments? For any company competing on data, whether it's in analyzing it or owning it? And for that matter: What is data, really? Beyond the existential questions, this episode of the a16z Podcast -

A lot of machine learning startups initially feel a bit of “impostor syndrome” around competing with big companies, because (the argument goes), those companies have all the data; surely we can’t beat that! Yet there are many ways startups can, and do, successfully compete with big companies. You can actually achieve great results in a lot of areas even with a relatively small data set, argue the guests on this podcast, if you build the right product on top of it. So how do you go about building the right product (beyond machine-learning algorithms in academic papers)? It’s about the whole system, the user experience, transparency, domain expertise, choosing the right tools. But what do you build, what do you buy, and do you bother to customize? Jensen Harris, CTO and co-founder of Textio, and AJ Shankar, CEO and co-founder of Everlaw, share their lessons learned here in this episode of the a16z Podcast — including what they wish they’d known early on. Because, observes moderator (and a16z board partner) Stev

Your brand, says head of a16z marketing and Outcast Agency co-founder Margit Wennmachers, is what people say about you when you're not in the room. And it's going to happen, whether you choose to have an active part in it or not. But what does this mean at an individual, not just company/product level? In this episode of the a16z Podcast, Wennmachers and Outcast CEO Alex Constantinople -- both longtime veterans of public relations and building executive profiles -- de-mystify what having and building a personal brand takes. It's not only about "thought leadership", either... a personal brand can also provide a filter for choosing what to do (and what not to do), as well as define your aspirations for where you want to go next. Even if you cringe at the idea of putting yourself in the spotlight. This conversation, moderated by a16z partner Hanne Tidnam, was recorded as part of the BreakLine Tech program for military veterans, an immersive education program for veterans transitioning into new careers

Starbucks supposedly spends more on healthcare than it does on coffee beans. And 20 years ago, says Rajeev Singh, CEO of Accolade, healthcare was 10% of GDP; today it’s 19% -- that's nearly one-fifths of our gross domestic product. So what tools do we have to address the high costs of health care, especially as stakeholders increasingly look for value-based care? This episode, recorded at our a16z inaugural Summit and moderated by Vijay Pande (a16z general partner on the bio fund) discusses approaches that combine new tech + people + data to address and improve healthcare. What are the macro trends driving innovations in the business of healthcare? And what will define the success of companies in this space? (Hint: it's not directly related to costs or healthcare reform.) The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources,

In this episode of the a16z Podcast introduced by Vijay Pande (based on a presentation at our summit event), Russ Altman, Stanford professor of bioengineering -- and former chairman of their Bioengineering Department -- takes us on a short but deep tour of the possibilities of genomics in drug discovery. Including how building a large bank of human genetic variations will change our understanding and optimization of drug response. Altman (who also hosts his own radio show, "The Future of Everything" on SiriusXM and Stanford radio) describes how in much the same way we inherit our grandmother's eyes, or our great grandfather's ears, we also inherit a response to certain drugs: whether they work or not, what side effects we'll experience, how we react to them. But it's not just genetics information that matters here; it's also molecular, cellular, tissue, and other data about the whole organism. By applying data science and bioinformatics on a more complete data "bank" like this, for the fir

The irony of our systems working so well -- technological, corporate, and yes, even political -- is that we've become too comfortable: matching to others just like us, producing less, taking fewer risks. But isn't the very point of technology to make our lives more comfortable? Yes... until "we" -- whether an entire class, generation, ethnic group, or country like the U.S. -- become a little too complacent. Or so argues Tyler Cowen in his new book, The Complacent Class: The Self-Defeating Quest for the American Dream. We've even outsourced our mobility to immigrants, observes Cowen (who is also a prolific economics blogger, columnist, and professor at George Mason University and director of the Mercatus Center there). Which is great... until you realize we're also giving up so much of that dynamism ourselves. This complacency affects everything from how economies to corporations to individuals grow, and we discuss how in this episode of the a16z Podcast (with Alex Rampell and Sonal Chokshi). "T

Humans have always wanted to enhance themselves -- from getting nutrition just-right to optimizing their performance, whether in sports or health or work. And food is a big part of all that. But our current systems of food production (and consumption) are far from efficient and sustainable let alone optimizable. That's where a whole new generation of wearable/ bio-feedback, food and nutrition, food production, and performance enhancement/ "nootropics" companies come in. How do these approaches move from the internet and online communities into the mainstream? Or from the university lab to the field? Or, put yet another way, from hobby to daily practice? After all, what we measure, what we take in, and what we output defines what it means to be human. We discuss this "future of you" in this episode of the a16z podcast with Daniel Chao, CEO of Halo Neuroscience; Rob Rhinehart, CEO of Soylent; James Rogers, CEO of Apeel; and Geoffrey Woo, CEO of Nootrobox -- based on a conversation with Chris

Imagine, for a moment, an alternative universe: One where Netflix got disrupted by some other streaming-content company that made its DVD rental business irrelevant. But that's just a counterfactual. What happened instead is that Netflix cannibalized (or rather, "hybridized") its own core business to make room for a more strategic one given where the tech was going. Given how rare it is for companies to successfully disrupt themselves like this, Reed Hastings, CEO and co-founder of Netflix, shares how they did it in this episode of the a16z Podcast (based on a conversation with Marc Andreessen that took place at our inaugural summit event). But please don't say "only the paranoid survive" -- Hastings believes business leaders need more sophisticated metaphors "to anticipate the paths, and all the judgment it takes, of deciding which competitive path to most explore". It also turns out that sourcing, managing, and supporting creative ideas and creators is not unlike the questions

Evolution and technology have allowed our human species to manipulate the physical environment around us -- reshaping fields into cities, redirecting rivers to irrigate farms, domesticating wild animals into captive food sources, conquering disease. But now, we're turning that "innovative gaze" inwards: which means the main products of the 21st century will be bodies, brains, and minds. Or so argues Yuval Harari, author of the bestselling book Sapiens: A Brief History of Mankind and of the new book Homo Deus: A Brief History of Tomorrow, in this episode of the a16z Podcast. What happens when our body parts no longer have to be physically co-located? When Big Brother -- whether government or corporation -- not only knows everything about us, but can make better decisions for us than we could for ourselves? That's ridiculous, you say. Sure... until you stop to think about how such decisions already, actually happen. Or realize that an AI-based doctor and teacher will have way more information than the

It's been nearly 15 years since the Human Genome Project was completed. But "are we there yet" in the golden age of genomics? What did we think we'd have by now, what do we actually have, and what do we really still need to make genomics live up to its promise? Well, one thing we now understand is that our DNA isn't static; in fact, it changes at an absolutely crazy rate. We also need to add more context -- about mutations, about somatic tissue, about phenotypes, about each person's unique history -- to make genetic information more complete and accurate. So what does that mean for predictive vs. diagnostic (which are two very different things) genomics? What are the challenges and opportunities for commercialization? The guests in this episode of the a16z Podcast -- Carlos Araya of Jungla,Jeff Kaditz of Q, and Gabe Otte of Freenome -- discuss all this and more with a16z bio fund partner Malinka Walaliyadde in a conversation that took place at our inaugural a16z Summit event.

The hardest thing about pivots (major shifts in company/product direction) isn't just the actual pivot. It's the courage to make the decision... and being honest with yourself as a CEO. Especially since, no matter how great the team or board or even customers may be, it's lonely: You're the only one in the position to synthesize the knowledge; nobody else has the data and the insight put together in the same way. And sigh, "pivot" has also become such an overused word, it's certainly lost nuance, and perhaps even meaning. So what does "pivoting" a startup really mean? For decision making? Timing (or time left until you run out of cash)? Culture? Are things different for so-called “hard tech” or deep research-based startups? Finally, how do you know when things are working, that you really do have product-market fit? a16z co-founder Ben Horowitz and Lytro CEO Jason Rosenthal discuss (in conversation with Sonal Chokshi) all this and more in this episode of the a16z podcast, sharing war stori

The modern enterprise holds all sorts of applications, devices, and workflow needs. How should we be thinking about securing infrastructure -- and identity -- in this context, for entities like major news media outlets or financial institutions such as News Corp or NASDAQ? Well, this episode of the a16z Podcast brings those voices together: Frederic Kerrest, cofounder and COO of Okta; Brad Peterson, CIO of NASDAQ; and Dominic Shine, CIO of News Corp ... in conversation with Ben Horowitz at our recent a16z Summit. What's the big security picture for these types of organizations, and others? How should we prepare? Last year's DINE DDoS attack was just one glimpse of what's to come, providing a bit of a barometer read for what's currently working, and what desperately needs re-engineering. One interesting solution involves decentralization; but as we move towards such technology (like blockchain) in security, what will high-frequency trading look like? How will consumer relationships, transactions, UI/design sec