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AUA2024: Ramon Guiteras Lecture: Modern Innovation: Promise or Peril? Presenter: Craig Niederberger, MD, FACS

AUA Leadership and Business Podcast: Urology Practice Manage - Overcoming Operational Challenges This episode is brought to you by the AUA Leadership and Business Podcast, where urologic professionals experience the practical application of business acumen essential to successfully navigating today’s rapidly changing business environment! Subscribe today via your favorite podcast app.

Focal Therapy Options for Prostate Cancer AUA Urology Core Curriculum: auau.auanet.org/core Host: Jay D. Raman, MD, FACS, FRCS(Glasg) Guest: Ruben Olivares, MD Outline: Segment 1: Why Focal Therapy? Segment 2: Patient selection for Focal Therapy Segment 3: Review of Existing Focal Therapy Modalities Segment 4: How to Build a Successful Focal Therapy Program

Hereditary Kidney Cancer Syndromes CME Available: https://auau.auanet.org/node/41772 ACKNOWLEDGEMENTS: Support provided by an independent educational grant from:  Merck & Co., Inc.  LEARNING OBJECTIVES: At the conclusion of this activity, participants should be able to: 1. Select patients who should undergo genetic testing to identify hereditary kidney cancer syndromes based on appropriate criteria, including family history and clinical presentation. 2. Implement strategies to address ethical concerns related to genetic testing, such as patient consent, confidentiality, and the potential impact on family members. 3. Discuss VHL syndrome, including its genetic basis, inheritance pattern, and associated tumors. 4. Properly diagnose and manage VHL syndrome in clinical practice based on knowledge of novel therapeutic strategies. 5. Utilize a multidisciplinary approach consisting of urologists, oncologists, geneticists and nephrologists when managing hereditary kidney cancer syndromes.

Prostate Cancer Update (2024): Expert Guidance for Urologists CME Available: https://auau.auanet.org/node/41868 Acknowledgements Support provided by independent educational grants from: Astellas Lantheus Medical Imaging Novartis Pharmaceuticals Corporation Pfizer, Inc. Learning Objectives At the conclusion of this activity, the learner will: 1. Align their practice with current AUA Guidelines (and recent amendments) pertaining to Screening, Diagnosis, and Management of Prostate Cancer. 2. Determine appropriate use of biomarker testing as it relates to diagnosis and therapy. 3. Analyze the role of imaging and types of imaging that aid in staging patients with prostate cancer. 4. Implement appropriate treatment paradigms for metastatic prostate cancer including treatment intensification. 5. Discuss the role of genetic and molecular profiling in the personalization of prostate cancer treatment plans.

Treatment Intensification in Metastatic HSPC CME Available: https://auau.auanet.org/node/41733 ACKNOWLEDGEMENTS: Support provided by independent educational grants from:  Lantheus Medical Imaging Novartis Pharmaceuticals Corporation LEARNING OBJECTIVES: At the conclusion of this activity, participants will be able to: 1. Explain the rationale behind treatment intensification in metastatic hormone sensitive prostate cancer (mHSPC), based on its pathophysiology.  2. Analyze the rationale and clinical evidence supporting treatment intensification in mHSPC, including potential benefits and risks.  3. Select appropriate patients for treatment intensification, considering factors such as disease burden, patient comorbidities, and individual risk profiles.

Appropriate Use of Genetic Testing (who, what, when and how?) CME Available: https://auau.auanet.org/node/41734 ACKNOWLEDGEMENTS: Support provided by independent educational grants from:  Lantheus Medical Imaging Novartis Pharmaceuticals Corporation LEARNING OBJECTIVES: At the conclusion of this activity, participants will be able to: 1. Identify the patient populations that should be considered for genetic testing in prostate cancer, based on family history, personal risk factors, and clinical indications. 2. Integrate genetic testing into clinical practice for prostate cancer, including developing workflows, referral processes, and multidisciplinary collaboration. 3. Utilize genetic test results to inform personalized treatment plans for prostate cancer patients, including targeted therapies and risk reducing strategies.

Sequencing Of Agents CME Available: https://auau.auanet.org/node/41735 ACKNOWLEDGEMENTS: Support provided by independent educational grants from: Lantheus Medical Imaging Novartis Pharmaceuticals Corporation LEARNING OBJECTIVES: At the conclusion of this activity, participants will be able to: 1. Review the latest evidence and clinical guidelines that inform the sequencing of therapeutic agents in metastatic prostate cancer, including data from key clinical trials. 3. Implement strategies for managing and overcoming resistance to therapy in metastatic prostate cancer, considering the role of sequencing in delaying resistance. 4. Apply best practices for monitoring treatment response and disease progression in patients undergoing therapy, and adjust sequencing strategies based on these observations.

Urologic Oncology: Genetics And Genomics AUA Urology Core Curriculum: auau.auanet.org/core Host: Jay D. Raman, MD, FACS, FRCS(Glasg) Guest: Hong Truong, MD, MS Outline: Segment 1: Genetics 101 – How Genes Influence Cancer Risk Segment 2: Genetic Risk Assessment Segment 3: Genetics of Kidney Cancer Segment 4: Genetics of Upper Tract Cancer Segment 5: Genetics of Prostate Cancer

Biomarkers and Molecular Imaging for Prostate Cancer CME Available: https://auau.auanet.org/node/41727 ACKNOWLEDGEMENTS: Support provided by independent educational grants from:  Lantheus Medical Imaging Novartis Pharmaceuticals Corporation LEARNING OBJECTIVES: At the conclusion of this activity, participants will be able to: 1. Explain the principles of molecular imaging and its application in prostate cancer, including techniques such as PET, MRI, and novel radiotracers. 2. Evaluate recent advances in molecular imaging technologies and their role in improving the accuracy of prostate cancer diagnosis, staging, and treatment monitoring. 3. Define and classify different types of biomarkers relevant to prostate cancer, including diagnostic, prognostic, and predictive biomarkers.

Kidney Cancer & SBRT in the Management of RCC AUA Urology Core Curriculum: auau.auanet.org/core Host: Jay D. Raman, MD, FACS, FRCS(Glasg) Guest: Daniel Shapiro, MD Outline: Segment 1: History of radiation therapy in renal cell carcinoma Segment 2: Radiation use in the setting of primary kidney tumors Segment 3: Radiation use for locally advanced tumors including tumor thrombi Segment 4: Radiation therapy for metastatic disease Segment 5: Limitations of radiation therapy and selecting patients for radiation therapy

Pediatric Urology: Differences of Sex Development AUA Urology Core Curriculum: auau.auanet.org/core Host: Jay D. Raman, MD, FACS, FRCS(Glasg) Guest: Emilie Johnson, MD, MPH, FACS, FAAP Outline: Segment 1: DSD Nomenclature – Words Matter! Segment 2: Multidisciplinary Care Model Segment 3: Example Conditions Segment 4: Approach to Prenatal and Early Postnatal Care Segment 5: Gonadal Management – also evolving

How to use Prostate-Specific Membrane Antigen-Positron Emission Tomography/CT in the Management of Relapsing Prostate Cancer Patients following Local Therapy with Curative Intent CME Available: https://auau.auanet.org/node/41124 At the conclusion of this activity, participants will be able to: 1. Identify the clinical scenario in which PSMA PET/CT is most helpful to identify the localization and extent of locoregional or systemic metastatic disease. 2. Identify the pitfalls of false-positive and false-negative PSMA PET/CT findings. 3. Apply the findings of PSMA PET/CT for the best individual therapeutic approach. 4. Identify patients with radiorecurrent organ-confined prostate cancer. 5. Identify those patients who are candidates for local therapy of oligometastatic disease in relapsing prostate cancer. ACKNOWLEDGEMENTS This educational activity is supported by independent educational grants from: Astellas, Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC, Lantheus Medical Imaging, M

The Changing Face of Advanced Prostate Cancer 2024 CME Available: https://auau.auanet.org/node/41136 At the conclusion of this activity, participants will be able to: 1. Identify and treat a patient with newly diagnosed M1 prostate cancer with androgen deprivation therapy plus be able to offer novel ADT. Furthermore, recognize high-volume new M1 prostate cancer so as to be able to refer to a genitourinary medical oncologist for chemotherapy if necessary. 2. Diagnose M0 CRPC, and be able to educate patients about using novel oral androgen receptor inhibitors added to traditional androgen deprivation therapy as a way to improve their patent's overall and radiographic progression-free survival. Furthermore, understand the differences between these novel oral agents and educate patients about side effects and toxicities. Finally, understand the role or lack of role of prostate-specific membrane antigen PET in working up this disease state. 3. Apply the latest phase III randomized controlled trial results for ne

Now in its 43rd installment, the AUA Update Series is renowned for delivering high-quality lessons to practicing urologists, fellows and residents. All content is developed by internationally recognized experts in urology, making the AUA Update Series the most professional and sought-after self-study program available. Improve your practice and patient care by staying abreast of the latest treatments and surgical techniques in urology. For more information or to subscribe to the AUA Update Series, please visit AUAnet.org/Update24

Prostate Cancer Diagnosis: AUA Guidelines on use of PSA Biomarkers, MRI and Biopsy Techniques CME Available: https://auau.auanet.org/node/41113 At the conclusion of this activity, participants will be able to: 1. Apply the Early Detection of Prostate Cancer: AUA/SUO Guideline (2023), and understand the rationale, evidence, level of evidence, strength of recommendation and applications associated with each statement. 2. Identify how to maximize the benefits and minimize the harms of prostate cancer detection by carefully selecting patients and by using the necessary tools to detect clinically significant prostate cancer, while avoiding unnecessary biopsies and detection of clinically insignificant prostate cancers. 3. Identify the evidence supporting the use of PSA for early detection of prostate cancer, and apply that evidence to different clinical scenarios, incorporating patient characteristics and preferences. 4. Identify available blood, urine and tissue biomarkers used to enhance detection of higher-g

Incorporating Genomic Testing and Advanced Imaging For Prostate Cancer Into Your Practice CME Available: https://auau.auanet.org/node/41033 At the conclusion of this activity, participants will be able to: 1. Identify the research that led to the approval of genomic cancer for prostate cancer and the implementation of advanced imaging for prostate cancer. 2. Order appropriate genomic testing and advanced imaging based on a patient's unique clinical situation. 3. State the National Comprehensive Cancer Network Guidelines for genomic testing and advanced imaging for prostate cancer. 4. Discern the different prognostic end points provided by various genomic tests. 5. Recognize candidates for, and implications of, germline testing for prostate cancer. ACKNOWLEDGEMENTS This educational activity is supported by independent educational grants from: Astellas, Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC, Lantheus Medical Imaging, Merck & Co., Inc., Novartis Pharmaceuticals Corporation, Pf

AUA2024: Upper Tract Urothelial Cancer (UTUC) Guidelines Upper Tract Urothelial Cancer (UTUC) Guidelines – An Interactive and Evidence-Based Course Highlighting the Full Spectrum of Disease via Case Discussion and Video Presentation CME Available: https://auau.auanet.org/node/41021 At the conclusion of this activity, participants will be able to: 1. Identify demographics, predisposing risks, hereditary factors, common terms. 2. Describe workup, imaging, role of standardized endoscopic assessment, cytology and biopsy. 3. Apply clinical features of disease risk, role of risk assessment and management options. 4. Identify candidates for endo management, describe counseling/risks, safe approaches, troubleshooting. 5. Explain setting and role for adjunctive chemotherapy use, importance of renal function, genetic counseling; describe approach to ureterectomy/bladder cuff, node dissection templates, intravesical therapy use; explain the rationale and use of risk-adjusted follow-up for endoscopy and imaging. ACKN

The Surgical Management of BPH and Updates from the AUA Clinical Guidelines Podcast (2024) CME Available: https://auau.auanet.org/node/41595 ACKNOWLEDGEMENT: This educational series is supported by an independent educational grant from Olympus Corporation of the Americas. At the conclusion of this activity, participants will be able to:   1. Describe the role of the AUA Clinical Guideline on the Management of Lower Urinary Tract Symptoms Attributed to Benign Prostatic Hyperplasia. 2. Discuss the evidence base for current technologies, including pivotal studies, and be able to define the role and clinical expectation for each of them. 3. Interpret the current clinical results and compare the patient experiences of these treatments in relation to more established and even abandoned treatments for patient groups with similar characteristics. 4. Differentiate between each of the new technologies for treating BPH/LUTS based on both their mode-of-action and the quality of their supporting evidence.

New AUA Guideline (2024): Salvage Therapy for Prostate Cancer CME Available: https://auau.auanet.org/node/41074 At the conclusion of this activity, participants will be able to: 1. Identify and effectively interpret the optimal timing of salvage radiation therapy following radical prostatectomy, considering the factors that can influence this decision in a clinical context. 2. Develop an understanding of which patients should receive ADT alongside salvage radiation therapy following radical prostatectomy, and how to appropriately decide the duration of ADT for patients. 3. Identify and analyze the use of risk stratification tools and next-generation imaging techniques for guiding treatment decisions and monitoring in patients with biochemical recurrence following primary therapy. 4. Evaluate the role and benefits of advanced treatment options such as intensified systemic therapy and metastasis-directed therapy. 5. Evaluate and understand the indications, efficacy, and potential complications of different sa